University and Hospital of Perugia, Italy
After graduation in Medicine and residency in Hematology at the University of Perugia (Italy) under the supervision of Prof. M. F. Martelli and Prof. B. Falini, Enrico Tiacci trained in the molecular pathogenesis of lymphomas at the University of Essen (Germany) in the laboratory of Prof. R. Küppers.
He then established an independent translational and clinical research program in leukemias and lymphomas at the University and Hospital of Perugia, where he is Associate Professor of Hematology.
His most relevant recent scientific contributions to pathogenesis, diagnosis and therapy of blood cancers include the following:
- The discovery of BRAF mutation as the genetic cause of hairy cell leukemia, its diagnostic exploitation and its therapeutic targeting in the clinic.
- The discovery of disruptive BCOR mutations in acute myeloid leukemias
- The study of high-risk clonal hematopoiesis in patients with myeloid and lymphoid neoplasms
- The transcriptional characterization of classical Hodgkin lymphoma (cHL) and of its potential normal cell counterpart (CD30+B cells), followed by the definition of the cHL coding genome and the identification of new frequently mutated genes in this neoplasm (e.g., STAT6 and GNA13).
He published as main author and acted as reviewer in journals like the New England Journal of Medicine, Blood, Journal of Clinical Oncology, Lancet Oncology and Journal of Clinical Investigations.
He received national and international recognitions for his achievements, including:
- International “Future Leaders in Hematology Award” from Celgene (selection by an independent scientific committee; San Diego – CA, USA – 2011)
- Scholarship in Clinical Research awarded from the Leukemia and Lymphoma Society (USA – 2013)
- Consolidator Grant from the European Research Council (2014)
- International “Young Investigator Award” for Clinical Research in Hematology from Celgene (selection by an independent scientific committee; Orlando – FL, USA – 2015)
- International “Francesco De Luca” Award for Cancer Research from the National Lyncean Academy (Accademia Nazionale dei Lincei; Rome, Italy – 2017)